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 General Gastroenterology

Whipple’s disease

Whipple’s disease


Definition:

Whipple's disease is a rare condition in which infection makes the intestine unable to properly absorb nutrients. This is called malabsorption.

Alternative Names:
Intestinal lipodystrophy
Causes, incidence, and risk factors:

Whipple's disease is most likely caused by infection with Tropheryma whippelii. The disorder primarily affects middle-aged white men, and the onset of symptoms is usually slow. Without treatment, it may be fatal.

Whipple's disease is extremely rare, and risk factors are unknown.

Symptoms:
Signs and tests:

Primary tests:

  • Small bowel biopsy showing infection-fighting cells containing bacteria (other body parts can also be biopsied)
  • Complete blood count (CBC) showing anemia
This disease may also alter the results of the following tests:

Review Date: 12/19/2006
Reviewed By: D. Scott Smith, M.D., MSc, DTM&H, Chief of Infectious Disease & Geographic Medicine, Kaiser Redwood City, CA & Adjunct Assistant Professor, Stanford University. Review provided by VeriMed Healthcare Network.

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