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 Liver Disease

Gilbert's disease

Gilbert's disease

Digestive system
Digestive system
Digestive system organs
Digestive system organs

Definition:

Gilbert's disease is a common disorder passed down through families that affects the way bilirubin is processed by the liver and causes jaundice.

Alternative Names:
Icterus intermittens juvenilis; Low-grade chronic hyperbilirubinemia; Familial non-hemolytic-non-obstructive jaundice; Constitutional liver dysfunction; Unconjugated benign bilirubinemia
Causes, incidence, and risk factors:

Gilbert's disease affects up to 10% of some Caucasian populations. The condition is usually benign.

Symptoms:
  • Mild jaundice (yellowing of skin and whites of eyes)
  • Fatigue

Note: Jaundice typically appears during times of exertion, stress, not eating, and infection.

Signs and tests:

An indirect bilirubin blood test shows changes consistent with Gilbert's disease.


Review Date: 5/3/2007
Reviewed By: Jenifer K. Lehrer, MD, Department of Gastroenterology, Frankford-Torresdale Hospital, Jefferson Health System, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

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