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 Neuro-Ophthalmology

Pseudotumor cerebri

Pseudotumor cerebri

Central nervous system
Central nervous system

Definition:

Pseudotumor cerebri is a process affecting the brain that appears to be -- but is not -- a tumor. It is often reversible.

Alternative Names:
Idiopathic intracranial hypertension; Benign intracranial hypertension
Causes, incidence, and risk factors:

The cause for the condition is unknown.

Certain medicines can increase your risk for this condition. These medicines include:

  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Tetracycline
  • Nitrofurantoin
  • Isotretinoin
  • Minocycline
  • Tamoxifen
  • Nalidixic acid
  • Lithium
  • Steroids (starting or stopping them)

The following factors also increase your risk:

The condition occurs more frequently in women than men, particularly in premenopausal obese women. It is rare in infants.

Symptoms:

The major symptom is increased pressure within the skull (increased intracranial pressure). There is no evidence of tumor, infection, blocked drainage of the fluid surrounding the brain, or any other cause.

Symptoms include:

  • Headache
  • Buzzing sound in the ears (tinnitus)
  • Dizziness
  • Nausea
  • Double vision (diplopia)
  • Partial or permanent loss of vision. Patients often complain of blurred vision.

Symptoms may get worse during physical activity, especially when tightening the stomach muscles.

Signs and tests:

The doctor will perform a physical exam. Signs of this condition include:

  • Swelling of a small area in the back of the eye (papilledema)
  • Increased head size
  • Bulging anterior fontanelle in babies whose cranial sutures are not yet closed

Despite the increased pressure in the skull, there is no change in alertness.

Tests that may be done include:

  • CT Scan
  • MRI
  • Lumbar puncture (spinal tap)
  • Eye exam, including formal visual field testing

The diagnosis is made when other health conditions are ruled out. Several conditions may cause increased intracranial pressure, including venous sinus thrombosis, hydrocephalus, and an intracranial mass (such as a tumor).


Review Date: 1/17/2008
Reviewed By: A.D.A.M. Editorial Team: David Zieve, MD, MHA, Greg Juhn, MTPW, David R. Eltz, Kelli A. Stacy, ELS. Previously reviewed by Daniel Kantor, MD, Director of the Comprehensive MS Center, Neuroscience Institute, University of Florida Health Science Center, Jacksonville, FL. Review provided by VeriMed Healthcare Network (3/5/2007).

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2002 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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