Polycystic ovary disease is a condition in which there are many small cysts in the ovaries, which can affect a woman's ability to get pregnant.

Polycystic ovary disease affects hormone cycles. Hormones help regulate the normal development of eggs in the ovaries. It is not completely understood why or how hormone cycles are interrupted, although there are several ideas.

Follicles are sacs within the ovaries that contain eggs. In polycystic ovary disease, there are many poorly developed follicles in the ovaries. The eggs in these follicles do not mature and, therefore, cannot be released from the ovaries. Instead, they form cysts in the ovary.

This can contribute to infertility. The immature follicles and the inability to release an egg (ovulate) are likely caused by low levels of follicle stimulating hormone (FSH), and higher-than-normal levels of male hormones (androgens) produced in the ovary.

Women are usually diagnosed when in their 20s or 30s. Women with this disorder often have a mother or sister who has symptoms similar to polycystic ovary disease.

If you have polycystic ovary disease, you are likely to have some of the following symptoms:

• Abnormal, irregular, or very light or infrequent menstrual periods
• Absent periods, usually (but not always) after having one or more normal menstrual periods during puberty (secondary amenorrhea)
• Acne that gets worse
• Decreased breast size
• Development of male sex characteristics (virilization), such as increased body hair, facial hair, a deepening of the voice, male-pattern baldness, and enlargement of the clitorus.
• Diabetes
• Increased hair growth; body hair may be in a male pattern
• Infertility
• Poor response to the hormone, insulin (insulin resistance), leading to a build-up of insulin in the blood
• Weight gain, or obesity

During a pelvic examination, the health care provider may note an enlarged clitoris (very rare finding) and enlarged ovaries.

Tests include:

• Abdominal ultrasound
• Abdominal MRI
• Biopsy of the ovary
• Estrogen levels
• Fasting glucose and insulin levels
• FSH levels
• Laparoscopy
• LH levels
• Male hormone (testosterone) levels
• Urine 17-ketosteroids
• Vaginal ultrasound

Blood tests that may be done include:

• Pregnancy test (serum HCG)
• Prolactin levels
• Thyroid function tests